Volkova M.V.*, Kunder E.V.**, Generalov I.I.*, Roggenbuck D.***
Antiphospholipid antibodies: modern concepts of the pathogenetic action and laboratory determination
*Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
**State Educational Establishment "Belarusian Medical Academy of Post-Graduate Education", Republic of Belarus
***Brandenburg University of Technology, Germany
Abstract.
The study of antiphospholipid syndrome is a priority for modern health care. This is due to the high demographic significance of this pathology. Antiphospholipid antibodies greatly contribute to the development of obstetric pathology, such conditions as miscarriage, premature birth, and others. Also antiphospholipid antibodies significantly affect the development of fatal thrombotic events (myocardial infarction, cerebral infarction) in all age groups. Laboratory diagnosis of antiphospholipid syndrome has objective difficulties because of low sensitivity of enzyme immunoassay. Nowadays new antiphospholipid antibodies tests based on linear immunoassay method are developed. They have higher sensitivity in comparison with enzyme immunoassay. This review discusses recent data on the pathogenesis, clinical manifestations of antiphospholipid syndrome and new diagnostic approaches in the antiphospholipid antibodies determination.
Key words: antiphospholipid antibodies, antiphospholipid syndrome, enzyme immunoassay, linear immunoassay.
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