The increase of the organism’s resistance to stress with iodine-containing thyroid hormones
Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
In the experiments on 255 mongrel male rats it has been established that the alarm stage of stress reaction (1 hour after stress, simulated by swimming of the rats in a cage during 1 hour) developing on the background of increased serum concentration of iodine-containing thyroid hormones (ITH) is accompanied by an increase of trypsin-like activity (TLA) in the liver and blood. The resistance stage (48 hours after stress) is characterized by normalization of serum levels of ITH and TLA in the blood, as well as limitation of TLA increase in the liver. The exhaustion stage (10 days of one-hour stress) causes serum level decrease of ITH and the greatest stimulation of TLA, which leads to a profound fall of the organism’s resistance and death of 21% of animals. The introduction of mercazolil (25 mg/kg during 20 days), accompanied by decreased concentration of ITH in the blood at all stages of stress reaction, provokes more pronounced in comparison with euthyroid animals TLA activation in the liver and blood, causing significant fall of the organism’s resistance and death of 42% of rats at the exhaustion stage. L-thyroxin administered at doses provisionally called small (1,5-3 ng/kg during 28 days) at the alarm and exhaustion stages of stress reaction predetermines a slight change of serum level of ITH and limits the increase of TLA in the liver and blood, and at the resistance stage it predetermines the normalization of ITH concentration and TLA both in the liver and blood, thereby increasing the resistance of the organism and prevents death of animals at the exhaustion stage of stress reaction. The presence of strong correlation between TLA and the relative weight of the spleen and thymus, serum concentration of cortisol and insulin, rats’ physical endurance, gastric mucosa damage parameters, as well as their dependence on the thyroid status of the organism under stress demonstrate a new mechanism of ITH antistress effect – normalizing influence on the activity of the trypsin-like proteolytic enzymes, which justifies the possibility of lysosomal dysfunction correction and the increase of the organism’s resistance under these conditions by means of the administration of exogenous L-thyroxin physiological doses.
Key words: iodine-containing thyroid hormones, trypsin-like activity, organism’s resistance, stress.
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