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Aliakhnovich N.S., Novikov D.K.
Prevalence, application and pathological effects of titanium dioxide
Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Vitebsk, Republic of Belarus

Vestnik VGMU. 2016;15(2):7-16.

Titanium dioxide (IV) (TiO2) is a common additive in many consumer goods. After their use TiO2 gets into sewerage and then into the environment and interacts again with living organisms.
Diverse routes of TiO2 entry cause a high risk of humans and animals exposure. The traditional view on TiO2 as a poorly soluble low reactogenicity chemical should be revised taking into account the accumulating data on its interaction with proteins and the formation of complex compounds, as well as pathological effects of E171 food dye on the human body.
The survey of the obtaining, the properties and application of titanium dioxide has been made. The publications about white food dye use in the food, household, cosmetic and pharmaceutical industries have been analyzed. The available data on TiO2 pathological effects: cancerogenic, immunomodulatory and allergic on the humans’ and laboratory animals’ organisms have been presented.
Key words: titanium dioxide, white dye, white coloring, food additive, E171, Р25, TiO2.


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