DOI: https://doi.org/10.22263/2312-4156.2016.5.64
Chekalina N.I.
Correlation LINKS between the parameters of systemic inflammation, lipid profile and thyroid function in ischemic heart disease combined with autoimmune thyroiditis
Ukrainian Medical Stomatological Academy, Poltava, Ukraine
Vestnik VGMU. 2016;15(5):64-70.
Abstract.
Objectives. To study the correlation links of chronic systemic inflammation markers with indicators of blood lipid profile and thyroid function in patients with coronary heart disease (CHD) in the combination with autoimmune thyroiditis (AIT).
Material and methods. The study involved 30 patients with diagnosed CHD: stable angina, functional class II with concomitant AIT, euthyroidism. All patients were treated with b-blockers, statins, aspirin, and short-term nitrates, for at least one month prior to the study. In the peripheral blood we determined the content of interleukins (IL-1b, IL-10), tumor necrosis factor (TNF-a), mRNA of kappa inhibitor B a) (IkBa) of the nuclear transcription factor of kB (NF-kB), free thyroxine (free T4), thyroid stimulating hormone (TSH), antibodies to thyroid peroxidase (AB to TPO), circulating endothelial microparticles (CEМ) CD32+CD40+, fibrinogen (FG), total cholesterol (TC), cholesterol of low-density lipoproteins (LDL-C), cholesterol of high-density lipoproteins (HDL-C), triglycerides (TG), and then studied the relationships between variables using correlation analysis by Pearson or, on an abnormal distribution, by Spearman.
Results. In patients with stable CHD combined with AIT, in addition to the close correlation links between cholesterol, triglycerides and LDL cholesterol, we found positive correlation links of medium strength between mRNA IkBa and indicators of blood lipid profile, between TNF- and FG, CEM CD32+CD40+, C, between IL-10 and TG, cholesterol, IL-1b, between CEМ CD32+CD40+ and cholesterol, LDL cholesterol. Negative correlation links of average force were found between the free T4 and cholesterol, FG, IL-1 , and also between the AB to TPO and CEМ CD32+CD40+.
Conclusions. The conducted correlation analysis proves the pathogenetic links between chronic systemic inflammation, endothelial damage, dyslipidemia, and thyroid dysfunction.
Key words: ischemic heart disease, autoimmune thyroiditis, chronic systemic inflammation, dyslipidemia, thyroid function, correlation.
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Information about authors:
Chekalina N.I. – Candidate of Medical Sciences, associate professor of the Chair of Propedeutics of Internal Medicine with Patients Care, General Practice, Ukrainian Medical Stomatological Academy.
Correspondence address: Ukraine, 36000, Poltava, 23 Shevchenko str., Ukrainian Medical Stomatological Academy, Chair of Propedeutics of Internal Medicine with Patients Care, General Practice. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Chekalina Natalya I.
