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Burdashkina K.G., Bychko G.N., Kirkovsky V.V., Rineyskaya O.N.
Restricted proteolysis products: approaches to the detection and diagnostic means for the evaluation of the pathology severity in endogenous intoxication
Belarusian State Medical University, Minsk, Republic of Belarus

Vestnik VGMU. 2016;15(6):21-27.

The review article is devoted to the urgent problem of the evaluation of the pathological process course severity in conditions accompanied by endogenous intoxication.
Various methodological approaches to the middle molecular peptide fraction determination as the main marker of endotoxemia are considered in this article. Modern data on quantitative and qualitative analysis of protein-peptide components in blood plasma by hydrophilic/hydrophobic properties, the peculiarities of proteinase-inhibitor system functioning in different types of pathology are presented. The analysis of molecular weight distribution nature of the products of intermediate protein metabolism will enable the increase of the reliability of the pathological process diagnosis and detoxication measures effectiveness monitoring.
Key words: restricted proteolysis products, proteinase-inhibitor system, endogenous intoxication.


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Information about authors:
Burdashkina K.G. – postgraduate of the Chair of Bioorganic Chemistry, Belarusian State Medical University;
Bychko G.N. – Candidate of Biological Sciences, leading research officer of the Scientific-Research Department, Belarusian State Medical University;
Kirkovsky V.V. – Doctor of Medical Sciences, professor, principal research officer of the Scientific- Research Department, Belarusian State Medical University;
Rineyskaya O.N. – Candidate of Medical Sciences, associate professor, head of the Chair of Bioorganic Chemistry, Belarusian State Medical University.

Correspondence address: Republic of Belarus, 210116, Minsk, 83 Dzerzhinsky ave., Belarusian State Medical University, Chair of Bioorganic Chemistry. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.  – Burdashkina Kristina G.

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