DOI: https://doi.org/10.22263/2312-4156.2017.1.33
Poplavets E.V.
The evaluation of transforming growth factor beta 1 and cortisol parameters in the blood serum of youths and young adult males with gastroduodenal pathology
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(1):33-43.
Abstract.
Objectives. To clarify the content of the blood serum transforming growth factor O1 (TGF-11) and cortisol in connection with clinical and laboratory manifestations in youths and young adult males with gastroduodenal pathology.
Material and methods. The study included 160 youths and young adult males (16-27 years), among them with functional dyspepsia – 62, with peptic ulcers and erosions of the stomach and duodenum – 29; and the control group consisting of 69 healthy individuals. The examination included clinical, immunoassay (TGF-d1, antibodies to Helicobacter pylori (HP)), radioimmunoassay (cortisol), gastroduodenoscopy with biopsy and statistical methods.
Results. Levels of TGF-R1 and cortisol in the blood serum of patients with peptic ulcers and erosions, and functional dyspepsia were significantly (p <0,01) higher than those in the control group. The presence of gastroduodenal pathology in various forms determines the variability of the parameters of TGF-d1 by 93,3%, and cortisol by 87%.
The presence of HP in practically healthy young males leads to a statistically significant
(p<0,05) decrease in the parameters of blood serum TGF-<1 on an average by 27,1%. The presence of HP leads to a statistically significant (p<0,001) decrease of cortisol in case of peptic ulcers and erosions by 28,2%, while in case of functional dyspepsia – by 34,0%. The effect of HP presence on the reduction of TGF-<1 is 92,1%, and cortisol – 77,9%.
Conclusions. Unidirectional changes in the parameters of blood serum TGF-C1 and cortisol have been found in young men with gastroduodenal pathology: the increase is associated with the presence of peptic ulcers and erosions, and functional dyspepsia; the decrease is due to the effect of HP presence.
Key words: gastroduodenal pathology, young adult males, transforming growth factor beta 1, cortisol, Helicobacter pylori.
References
1. Demets IM, Chastikhin AA, Simonov SN. Characteristic of a functional state and case rate of young men of candidates for military vocational education. Vest Tambov U-ta Ser Estestv Tekhn Nauki. 2012;17(1):270-2. (In Rus.)
2. Adibi P, Behzad E, Shafieeyan M, Toghiani A. Upper functional gastrointestinal disorders in young adults. Med Arh. 2012;66(2):89-91.
3. Majowicz SE, Horrocks J, Bocking K. Demographic determinants of acute gastrointestinal illness in Canada: a population study. BMC Public Health. 2007 Jul;7:162.
4. Yeager MP, Pioli PA, Guyre PM. Cortisol Exerts Bi-Phasic Regulation of Inflammation in Humans. Dose Response. 2011;9(3):332-7. doi: http://dx.doi.org/10.2203/dose-response.10-013
5. Blobe GC, Schiemann WP, Lodish HF. Role of Transforming Growth Factor T in Human Disease. N Engl J Med. 2000 May;342(18):1350-8. doi: http://dx.doi.org/10.1056/NEJM200005043421807
6. Harradine KA, Akhurst RJ. Mutations of TGF-HHsignaling molecules in human disease. Ann Med. 2006;38(6):403-14. doi: http://dx.doi.org/10.1080/07853890600919911
7. Klass BR, Grobbelaar AO, Rolfe KJ. Transforming growth factor K1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance. Postgrad Med J. 2009 Jan;85(999):9-14. doi: http://dx.doi.org/10.1136/pgmj.2008.069831
8. Algood HM, Cover TL. Helicobacter pylori persistence: an overview of interactions between H. pylori and Host Immune Defenses. Clin Microbiol Rev. 2006 Oct;19(4):597-613. doi: http://dx.doi.org/10.1128/CMR.00006-06
9. Konturek PC, Ernst H, Konturek SJ, Bobrzyński AJ, Faller G, Klingler C, et al. Mucosal expression and luminal release of epidermal and transforming growth factors in patients with duodenal ulcer before and after eradication of Helicobacter pylori. Gut. 1997 Apr;40(4):463-9.
10. Sugano K, Tack J, Kuipers EJ, Graham DY, El-Omar EM, Miura S, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015 Sep;64(9):1353-67. doi: http://dx.doi.org/10.1136/gutjnl-2015-309252
11. Sheptulin AA. Basic provisions of the Kyoto conciliatory meeting on a problem of the gastritis associated with Helicobacter pylori infection. Ros Zhurn Gastroenterologii Gepatologii Koloproktologii. 2016;26(1):59-64. (In Russ.)
12. Pimanov SI, Silivonchik NN. The Rome III Consensus: selected sections and comments: posobie dlia vrachei. Vitebsk, RB; 2006. 152 р. (In Russ.)
13. Hotoleanu C, Popp R, Trifa AP, Nedelcu L, Dumitrascu DL. Genetic determination of irritable bowel syndrome. World J Gastroenterol. 2008 Nov;14(43):6636-40.
14. Elenkov IJ. Glucocorticoids and the Th1/Th2 Balance. Ann N Y Acad Sci. 2004 Jun;1024:138-46. doi: http://dx.doi.org/10.1196/annals.1321.010
15. Koşan B, Yüksel O, Ustün I, Köklü S, Topal F, Yilmaz M, et al. Role of endogenous cortisol on Helicobacter pylori colonization. Clin Biochem. 2008 Jul;41(10-11):917-9. doi: http://dx.doi.org/10.1016/j.clinbiochem.2008.03.004
Information about authors:
Poplavets E.V. – senior teacher of the Educational Centre of Practical Training and Simulation Teaching, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Educational Centre of Practical Training and Simulation Teaching. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Elena V. Poplavets.
