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Poplavets E.V.
The evaluation of transforming growth factor beta 1 and cortisol parameters in the blood serum of youths and young adult males with gastroduodenal pathology
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2017;16(1):33-43.

Objectives. To clarify the content of the blood serum transforming growth factor O1 (TGF-11) and cortisol in connection with clinical and laboratory manifestations in youths and young adult males with gastroduodenal pathology.
Material and methods. The study included 160 youths and young adult males (16-27 years), among them with functional dyspepsia – 62, with peptic ulcers and erosions of the stomach and duodenum – 29; and the control group consisting of 69 healthy individuals. The examination included clinical, immunoassay (TGF-d1, antibodies to Helicobacter pylori (HP)), radioimmunoassay (cortisol), gastroduodenoscopy with biopsy and statistical methods.
Results. Levels of TGF-R1 and cortisol in the blood serum of patients with peptic ulcers and erosions, and functional dyspepsia were significantly (p <0,01) higher than those in the control group. The presence of gastroduodenal pathology in various forms determines the variability of the parameters of TGF-d1 by 93,3%, and cortisol by 87%.
The presence of HP in practically healthy young males leads to a statistically significant
(p<0,05) decrease in the parameters of blood serum TGF-<1 on an average by 27,1%. The presence of HP leads to a statistically significant (p<0,001) decrease of cortisol in case of peptic ulcers and erosions by 28,2%, while in case of functional dyspepsia – by 34,0%. The effect of HP presence on the reduction of TGF-<1 is 92,1%, and cortisol – 77,9%.
Conclusions. Unidirectional changes in the parameters of blood serum TGF-C1 and cortisol have been found in young men with gastroduodenal pathology: the increase is associated with the presence of peptic ulcers and erosions, and functional dyspepsia; the decrease is due to the effect of HP presence.
Key words: gastroduodenal pathology, young adult males, transforming growth factor beta 1, cortisol, Helicobacter pylori.


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Information about authors:
Poplavets E.V. – senior teacher of the Educational Centre of Practical Training and Simulation Teaching, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Educational Centre of Practical Training and Simulation Teaching. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Elena V. Poplavets.

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