Karpuk I.Y., Novikov D.K.
The significance of eosinophilic cationic protein in the oral fluid of patients with orthopedic constructions bioincompatibility
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(4):104-110.
Objectives. To analyze the level of eosinophilic cationic protein in the oral fluid and to establish its relationship with morphological changes in the oral mucosa of patients with intolerance to dental materials and prosthetic stomatitis.
Material and methods. 75 patients aged from 32 to 74 years, with the complaints of intolerance to dental materials and prosthetic stomatitis were examined.
During the clinical examination, patients complaining of intolerance to dental materials and prosthetic stomatitis were divided into 4 groups: the 1st group (n=18) included patients with objective clinical symptoms of intolerance to dental materials; the 2nd group (n=20) consisted of patients with prosthetic stomatitis and identified Candida; the 3rd group (n=20) was composed of patients with prosthetic stomatitis, without the lesion by fungi of the genus Candida; the 4th group (n=17) included patients without objective clinical symptoms, but with complaints of intolerance to dental materials. The control group (n=15) consisted of patients without any complaints of intolerance to dental materials.
Results. The study of eosinophilic cationic protein in the oral fluid for various variants of orthopedic constructions bioincompatibility showed the relationship between the level of eosinophilic cationic protein and the presence of eosinophils on the morphometric analysis of the oral mucosa samples of patients. Inflammatory-dystrophic and inflammatory-allergic types of cytograms of the oral mucosa were distinguished in patients with intolerance to dental materials.
Conclusions. In patients with objective signs of intolerance to dental materials and in patients with prosthetic stomatitis and the presence of allergy to the components of dental materials, the level of eosinophilic cationic protein and eosinophils in the oral fluid was increased.
Key words: eosinophilic cationic protein, oral fluid, impression cytology, intolerance to dental materials, prosthetic stomatitis.
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Information about authors:
Karpuk I.Y. – Candidate of Medical Sciences, associate professor, doctoral candidate of the Сhair of Clinical Immunology & Allergology with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Novikov D.K. – Doctor of Medical Sciences, professor, head of the Chair of Clinical Immunology & Allergology with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.