DOI: https://doi.org/10.22263/2312-4156.2017.6.72
Boika A.V.1, Ponomarev V.V.1, Homichenko T.V.2
Sleep disturbance in Parkinson’s disease: the role of immune mechanisms
1Belarusian Medical Academy of Post-Graduate Education, Minsk, Republic of Belarus
2The 5-th City Clinical Hospital, Minsk, Republic of Belarus
Vestnik VGMU. 2017;16(6):72-78.
Abstract.
Introduction. Cytokines and cortisol are involved in the implementation of complex functions of the central nervous system and have an important influence on the development of neurodegenerative diseases and sleep-wake rhythm disturbances.
Objectives. To determine the correlation between the levels of IL-1β, IL-10, as well as cortisol in serum and cerebrospinal fluid (CSF) with the value of sleep disturbances in Parkinson’s disease (PD), assessed by means of scales: Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS).
Material and methods. 31 patients (males (M): females (F) = 0,94: 1; their age (median) was 66 years [58, 72]) of the main group (MG) and 8 persons of the control group (CG, (M: F = 3: 1, their age (median) was 60 years [58, 75])) were studied. The differences between the MG and the CG in age were not statistically significant (p=0,85). The investigation was approved by the ethical committees concerned. The use of diagnostic methods was carried out in accordance with the regulations of Helsinki Declaration of 1975. The collection of biological specimens (blood and CSF) was performed in the first half of the day.The evaluation of sleep disturbances was carried out in the morning after the intake of antiparkinsonian drugs. Nonparametric methods of statistics were used.
Results. A wide prevalence of sleep disorders in people with PD was confirmed. The differences between the MG and the CG were statistically significant (p≤0,05) by the ESS and PSQI scales. In the MG, statistically significant differences between subgroups F and M were obtained only by the PSQI scale (p=0,027). Statistically significant correlations between the value of daytime sleepiness and IL-10 levels in CSF (r=-0,48; p=0,02), and cortisol levels in serum (r=-0,45; p=0,03) were detected for individuals of the MG.
Conclusions. Neuroinflammation is involved in the pathogenesis of sleep disorders in PD. There is the prospect for further research in this direction.
Key words: neuroinflammation, Parkinson’s disease, cytokines, cortisol, sleep disturbance.
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Information about authors:
Boika A.V. – Candidate of Medical Sciences, doctoral candidate of the Chair of Neurology & Neurosurgery, Belarusian Medical Academy of Post-Graduate Education;
Ponomarev V.V. – Doctor of Medical Sciences, professor, head of the Chair of Neurology & Neurosurgery, Belarusian Medical Academy of Post-Graduate Education;
Homichenko T.V. – head of the neurologic department No. 2, the 5-th City Clinical Hospital.
Correspondence address: Republic of Belarus, 220013, Minsk, 3-3 P. Brovki str., Belarusian Medical Academy of Post-Graduate Education. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Alexander V. Boika.
