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Tkachenko A.S.1, Nakonechna O.A.1, Gorbach Т.V.1, Tkachenko M.A.2
Carrageenans: are they useful or detrimental?
1Kharkov National Medical University, Kharkov, Ukraine
2Kharkov Municipal Clinical Hospital No.27, Kharkov, Ukraine

Vestnik VGMU. 2018;17(1):7-13.

Carrageenans are sulfated heteropolysaccharides of red algae, that are used in the food industry as thickeners and emulsifiers (E407). Both positive and negative effects of carrageenans on the body have been reported. This review deals with information about the experiments in which the ability of carrageenans to act as inducers of inflammation and carcinogenesis is demonstrated, antioxidant, antiviral and antitumor effects of carrageenans are also described. After analyzing the sources, we have concluded that the properties of carrageenans depend primarily on the type and molecular weight of macromolecules. Controversial data on the toxic effects of carrageenans from in vivo and in vitro investigations indicate the need for careful interpretation of the results of experiments, that demonstrate the safety of the E407 food additive, and prevent from blindly transferring the results of in vitro studies of the biosafety of carrageenans to humans.
Key words: food additives, carrageenan, carrageenan-induced inflammation, antioxidants, antitumor effect.


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Information about authors:
Tkachenko A.S. – Candidate of Medical Sciences, lecturer of the Chair of Biochemistry, Kharkov National Medical University;
Nakonechna O.A. – Doctor of Medical Sciences, professor, head of the Chair of Biochemistry, Kharkov National Medical University;
Gorbach T.V. – Candidate of Biological Sciences, associate professor of the Chair of Biochemistry, Kharkov National Medical University;
Tkachenko M.A. – intern, Kharkov Municipal Clinical Hospital No.27.

Correspondence address: Ukraine, 61022, Kharkov, 4 Nauky ave., Kharkov National Medical University, Chair of Biochemistry. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Anton S. Tkachenko.

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