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Nemtsov L.M.1, Yupatau G.I.1, Gavrilenko L.A.2, Mlyaviy A.N.3, Kosinets N.S.2, Khvoshchyov A.V.1
Eosinophilic pathology of the large intestine
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Vitebsk Regional Clinical Specialized Centre, Vitebsk, Republic of Belarus
3Vitebsk Regional Clinical Pathoanatomical Bureau, Vitebsk, Republic of Belarus

Vestnik VGMU. 2018;17(4):7-21.

The article presents literature review on the problems of etiology, pathogenesis, diagnosis and management of eosinophilic pathology of the large intestine and the description of the clinical case with eosinophilic infiltration of the colonic mucosa from the authors’ own experience. The number of reports on "eosinophilic colitis" (EC), diagnosed by the presence of eosinophilic infiltration of the colonic mucosa in patients with intestinal symptoms significantly increased during the past 10-15 years. There is no consensus concerning its diagnosis and management. The diagnosis of primary EC is based on large intestine biopsy, which is an extremely difficult task in the absence of strict diagnostic criteria and requires careful elimination of all secondary causes. EC should often be considered as a nonspecific inflammatory response, taking into account a large number of known factors, including parasites and drugs, that are associated with secondary eosinophilic infiltration of the large intestine, non-specificity of clinical manifestations and the absence of correlation between the symptoms and the eosinophilic infiltrate density. The therapeutic approaches to EC are based on the analysis of a small series of clinical cases. Randomized controlled clinical trials are needed to determine precise clinical and pathomorphological diagnostic criteria for EC and the strategy of its management.
Key words: eosinophilic colitis, eosinophilic gastrointestinal disorder, eosinophils.


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Information about authors:
Nemtsov L.M. – Doctor of Medical Sciences, professor of the Chair of Internal Diseases Propedeutics, Vitebsk State Order of Peoples’ Friendship Medical University;
Yupatau G.I. – Doctor of Medical Sciences, professor, head of the Chair of Internal Diseases Propedeutics, Vitebsk State Order of Peoples’ Friendship Medical University;
Gavrilenko L.A. – head of the gastroenterological department, Vitebsk Regional Clinical Specialized Centre;
Mlyaviy A.N. – pathoanatomist, Vitebsk Regional Clinical Pathoanatomical Bureau;
Kosinets N.S. – gastroenterologist of the consultation-diagnosis gastroenterological office, Vitebsk Regional Clinical Specialized Centre;
Khvoshchyov A.V. – clinical resident of the Chair of Internal Diseases Propedeutics, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Internal Diseases Propedeutics. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Leonid M. Nemtsov.

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