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Prudnikov A.R., Shchupakova A.N.
The role of cytokines in the diagnosis of unstable atherosclerotic plaque
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2018;17(5):28-42.

The article is devoted to the role of cytokines in the diagnosis of atherosclerotic plaque instability and prognosis of adverse cardiovascular events.
At this moment atherosclerosis is considered not only as a disease due to the impaired functioning of the lipid transport system, but also as a long-term, sluggish chronic inflammation of the vascular wall with stable periods and exacerbations of the process. The process of destabilization of atherosclerotic plaque, its rupture and formation of thrombotic masses is the result of the direct participation of the immune system, which leads to the development of acute coronary events.
The mechanisms of atherosclerosis initiation, atherosclerotic plaque destabilization, as well as various diagnostic methods and the role of cytokines in determining the unstable course of atherosclerotic process are considered. Prospects for the use of cytokines as predictors of repeated cardiovascular events are outlined.
Key words: cytokines, plaque destabilization, diagnosing.


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Information about authors:
Prudnikov A.R. – Master of Medical Sciences, postgraduate of the Chair of Internal Medicine, Vitebsk State Order of Peoples’ Friendship Medical University;
Shchupakova A.N. – Doctor of Medical Sciences, professor of the Chair of Internal Medicine, pro-rector for treatment-and-pharmaceutical work and post-diploma education, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Internal Medicine. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Alexander R. Prudnikov.

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