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Belyaeva L.E., Pauliukevich A.N.
The early programming of human diseases and the application of nutraceuticals for their prevention: focus on fish oil. Literature review. Part I
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2019;18(4):7-16.

In the first part of this review the results of experimental, clinical and epidemiological investigations devoted to the study of the consequences of stressors action in the prenatal period have been analyzed. The basic mechanisms of diseases programming in the organisms whose mothers were exposed to various stressors action during pregnancy have been considered. An approach to minimize negative outcomes caused by the action of stressors on the body in the prenatal period with fish oil nutraceutical containing long-chain omega-3 polyunsaturated fatty acids – eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has been proposed. Metabolism peculiarities of these polyunsaturated fatty acids in the body have been discussed in the first part of the review as well.
Key words: prenatal stress, early programming of human diseases, epigenetics, long-chain omega-3 polyunsaturated fatty acids.


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Information about authors:
Belyaeva L.E. – Candidate of Medical Sciences, associate professor, head of the Chair of Pathologic Physiology, Vitebsk State Order of Peoples’ Friendship Medical University;
Pauliukevich A.N. – Master of Medical Sciences, lecturer of the Chair of Pathologic Physiology, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Pathologic Physiology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lyudmila E. Belyaeva.

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