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Zhuravleva L.N. Novikova V.I.
The significance of the blood serum biomarker presepsin in pneumonia in premature newborns
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2020;19(4):46-52.

Introduction. In the neonatal period, infectious pathology has nonspecific clinical manifestations, which can lead to difficulties in the interpretion of symptoms and late diagnosis of the disease.
Objectives. To determine the diagnostic significance of the blood serum presepsin (PSP) concentration in premature newborns with respiratory disorders for the early diagnosis of pneumonia.
 Material and methods. We included 62 preterm infants with the gestational age of 27-36 weeks in our research work. Respiratory pathology was observed in 47 newborns (congenital pneumonia was diagnosed in 20 children, and respiratory distress syndrome (RDS) – in 27 of them), and 15 preterm infants made up the control group.
Results. On the 1st – the 3rd day of life the analysis of presepsin concentration allowed to reveal that this early inflammatory marker was increased in children with respiratory pathology. Moreover, in children with congenital pneumonia this inflammatory marker was statistically increased compared to children with RDS (358.9 [279.8-675.7] and 245.6 [125-353], respectively). The same tendency remained in the dynamics of the neonatal period when we reexamined this indicator on the 7th – the 10th day of life. We found a statistically significant (p<0.05) positive interrelationship between blood serum presepsin level on the 1st – the 3rd day of life and the duration of mechanical ventilation (R=0.34; p=0.02), as well as between the PSP concentration on the 1st – the 3rd day of life and the number of days of antibiotic therapy (R=0.27, p=0.002).
Conclusions. The presepsin concentration of 325 ng / l in blood serum on the first three days of life can be used as a diagnostic criterion for the presence of pneumonia in children with RDS.
Key words: newborns, respiratory distress syndrome, pneumonia, immune status, presepsin.

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Information about authors:
Zhuravleva L.N. – Candidate of Medical Sciences, associate professor of the Chair of Pediatrics, Vitebsk State Order of Peoples’ Friendship Medical University;
Novikova V.I. – Doctor of Medical Sciences, professor, head of the Chair of Pediatrics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Pediatrics. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lyudmila N. Zhuravleva.

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