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DOI: https://doi.org/10.22263/2312-4156.2020.4.53

Lipnitski A.L.1, Tachyla S.A.1, Marochkov A.V.1, Borisov O.L.2, Antipenko A.A.2
The use of rheohepatography in a potential donor for evaluating hepatic graft function
1Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus
2Mogilev State University named after A.A. Kuleshov, Mogilev, Republic of Belarus

Vestnik VGMU. 2020;19(4):53-61.

Abstract.
Objectives. To identify changes in tetrapolar rheohepatography (RHG) values in potential donors before harvesting of organs and tissues for transplantation.
Material and methods. A prospective pilot study included 30 potential organs and tissues donors (patients with brain death), among them: men – 18 (60%), women – 12 (40%). The average age of a potential donor was 56 (49; 59) years. The cause of brain death was cerebrovascular disease in 25 (83.3%) patients, traumatic brain injury – in 5 (16.7%) patients. In all potential donors, tetrapolar rheohepatography was performed to evaluate the function of hepatic graft before harvesting of organs and tissues for transplantation.
Results. When comparing the RHG indicators in effective hepatic graft donors (n=9) and in donors without hepatic graft harvesting (n=21), statistically significant differences were revealed: fast blood filling time – 0.06 (0.05; 0.06) s and 0.05 (0.03; 0.05) s (p=0.05); total systole time – 0.37 (0.29; 0.45) s and 0.23 (0.22; 0.29) s (p=0.05); rheographic index – 0.53 (0.43; 0.95) cu. and 0.2 (0.14; 0.26) cu. (p<0.001); the maximum speed of fast filling – 0.55 (0.46; 1.62) ohm/s and 0.3 (0.2; 0.39) ohm/s (p=0.005), respectively.
Conclusions. The RHG indicators can be used as independent predictors of functional and morphological damage of the donor’s liver at the stage of conditioning functional systems of a potential donor.
Key words: brain death, potential donor, hepatic graft, liver transplantation, harvesting of organs, rheohepatography.
     
Information on the source of support in the form of grants, equipment, medicinal preparations. The research was conducted within the frames of the grant from the President of the Republic of Belarus in health care «For the development and application to clinical practice of new methods of diagnosing and conditioning of deceased donor’s functional systems with the purpose of increasing the efficacy of conditioning and subsequent transplantation of organs and tissues». (Decree of the President of the Republic of Belarus dated 19 January 2018, №32 rp).

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Information about authors:
Lipnitski A.L. – Candidate of Medical Sciences, anesthesiologist-resuscitator, head of the department for taking organs and tissues for transplantation, Mogilev  Regional Clinical Hospital,
ORCID: https://orcid.org/0000-0002-2556-4801;
Tachyla S.A. – Candidate of Medical Sciences, anesthesiologist-resuscitator of the anesthesiology & resuscitation department, Mogilev Regional Clinical Hospital,
ORCID: https://orcid.org/0000-0003-1659-5902;
Marochkov A.V. – Doctor of Medical Sciences, professor, anesthesiologist-resuscitator, Mogilev Regional Clinical Hospital,
ORCID: https://orcid.org/0000-0001-5092-8315;
Borisov O.L. – Candidate of Biological Sciences, associate professor, head of the Chair of Sports & Medicobiologic Disciplines, Mogilev State University named after A.A. Kuleshov;
Antipenko A.A. – Candidate of Biological Sciences, associate professor of the Chair of Sports & Medicobiologic Disciplines, Mogilev State University named after A.A. Kuleshov.

Correspondence address: Republic of Belarus, 212016, Mogilev, 12 Belynitsky-Birula str., Mogilev Regional Hospital, department for taking organs and tissues for transplantation. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Artur L. Lipnitski.

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