DOI: https://doi.org/10.22263/2312-4156.2020.5.40
Miklis N.I.1, Alekseyev I.S.2, Burak I.I.1, Doroshenko I.A.2, Goncharevich A.L.3, Ladik Y.S.1
Antimicrobial activity of the dressing material from nonwoven polymer nanofibers
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Vitebsk State Technological University, Vitebsk, Republic of Belarus
3Belarusian State University of Informatics and Radioelectronics, Minsk, Republic of Belarus
Vestnik VGMU. 2020;19(5):40-47.
Abstract.
Objectives. To determine the antimicrobial activity of the developed biocompatible biodegradable nonwoven polymer sorption dressing materials from porous nanofibers on the basis of polyvinyl alcohol and polyvinylpyrrolidone with antiseptics depending on the content of porofor.
Material and methods. Antimicrobial activity against standard museum strains of microorganisms has been investigated in 4 series of experiments with 9 samples of the developed nonwoven polymer sorption dressing materials from porous nanofibers, containing the mixture of polymers-carriers of polyvinyl alcohol and polyvinylpyrrolidone with porofor or without it and antiseptics.
Results. It has been established that all studied nonwoven polymer sorption dressing materials containing the mixture of polymers-carriers with 0.1% chlorhexidine, 0.05% colloidal silver or 5% tylosin, without addition or with addition of porofor, possess antimicrobial activity against museum test cultures of microorganisms E. coli, S. aureus, P. aeruginosa and C. albicans АТСС collection. The addition of 3% porofor to the mixture of polymers-carriers with chlorhexidine has slightly increased antimicrobial activity of the sample against standard microorganisms. The addition of 5% porofor has caused a more pronounced increase of antimicrobial activity, and that of 7% and 9% porofor resulted in reliable increase of antimicrobial activity against all studied test cultures.
The addition of 5% porofor to nonwoven polymer sorption dressing materials containing the mixture of polymers-carriers with tylosin has reliably increased antimicrobial activity of samples against all studied test cultures of microorganisms, and when combined with colloidal silver – against S. aureus.
So, the content of porofor not less than 5% as a part of dressing materials may be considered as optimal.
Conclusions. The received results allow to recommend conducting further trials of nonwoven fibrous materials on the basis of biocompatible biodegradable porous nanofibers as medical dressings and remedies for wound healing.
Key words: polymer nanofibers, antiseptics, porofor, dressing material, antimicrobial activity.
Information about the sources of financing. The research was conducted within the frames of the theme task 2.48 «Technology of nonwoven polymer sorption materials from porous nanofibers of veterinary and medical use received by means of electrospinning» of State Research Programs (GPNI) of the Republic of Belarus «Physical materials science, new materials and their technologies», №GR 20163067.
Acknowledgement. The authors express their gratitude to the head of the Chair of Clinical Microbiology of Vitebsk State Order of Peoples’ Friendship Medical University, Professor Generalov Igor Ivanovich for the help provided while conducting investigations.
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Information about authors:
Miklis N.I. – Candidate of Medical Sciences, associate professor, head of the Chair of General Hygiene & Ecology, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0002-7707-5882
Alekseyev I.S. – Candidate of Technological Sciences, associate professor of the Chair of Technology & Equipment of Mechanical Engineering Production, Vitebsk State Technological University,
ORCID: https://orcid.org/0000-0002-3213-7277
Burak I.I. – Doctor of Medical Sciences, professor of the Chair of General Hygiene & Ecology, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0002-7204-3056
Doroshenko I.A. – laboratory assistant of the Chair of Technology & Equipment of Mechanical Engineering Production, Vitebsk State Technological University;
ORCID: https://orcid.org/0000-0003-2970-5218
Goncharevich A.L. – lecturer of the Chair of Information Technologies of Automated Systems, Belarusian State University of Informatics and Radioelectronics;
Ladik Y.S. – the fifth-year medical student, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of General Hygiene & Ecology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Natalya I. Miklis.
