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DOI: https://doi.org/10.22263/2312-4156.2020.6.41

Gusakova E.A., Gorodetskaya I.V.
The restriction of sympathoadrenal system activity and the body’s resistance to stress
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2020;19(6):41-53.

Abstract.
Based on the analysis of monographs, results published in physiological and medical journals, as well as presented on Internet resources (search engines Google, Pubmed, eLIBRARY, selection of literature sources by key words – glucocorticoids, thyroid hormones), it has been found  out that the sympathectomy (chemical –  the introduction of drugs that inhibit the transmission of excitation in the synapses of the sympathetic nervous system, for example, guanethidine, 6-hydroxydopamine, reserpine, etc.; surgical – the  removal of the sympathetic ganglia; immune – the introduction of antibodies to the nerve growth factor) reduces the body’s resistance to stress, since it considerably  weakens the response of the hypothalamic-pituitary-adrenal and sympathoadrenal systems making it impossible to implement the adaptive effects of their hormones under these conditions. The following mechanisms of decreasing stress resistance during blockade of transmission of excitation in adrenergic synapses have been established: intensification of lipid peroxidation and proteolysis, impaired protein and carbohydrate metabolism, causing the appearance of dystrophic changes in various tissues; the  heart function disturbance , that ensures the activity of all systems making an  adaptation  to stress.
Key words: stress resistance, deficiency of sympathetic nerve effects.

The research was conducted within the frames of the theme task of State Research Programs (GPNI) of the Republic of Belarus for 2019-2020 «To study the possibility of increasing organism’s stress tolerance by stimulating the central part of antistress system and reducing the activity of stress- realizing system by means of purposeful correction of the thyroid status (experimental study)».

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Information about authors:
Gusakova E.A. – Candidate of Biological Sciences, associate professor of the Chair of General, Physical and Colloid Chemistry, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID:https://orcid.org/0000-0001-9150-5685;
Gorodetskaya I.V. – Doctor of Medical Sciences, professor of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID:https://orcid.org/0000-0002-7388-4244.

Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of General, Physical and Colloid Chemistry. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Elena A. Gusakova.

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