Kolbasova E.A.1, Kiseleva N.I.1, Naumov A.V.2
Sulfur-containing amino acids and their metabolite derivatives in women with climacteric syndrome in post-menopause
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2021;20(1):72-80.
Objectives. To study the indicators of the concentrations of sulfur-containing amino acids and their metabolites in the blood serum of women with surgical and natural menopause and to establish correlations with the severity of menopause syndrome, the level of gonadotropic and sex steroid hormones.
Material and methods. We examined 192 women, 93 of them with surgical menopause (group I), 68 with natural menopause (group II), 31 in late reproductive and premenopausal ages (control group). The patients underwent a study of the content of homocysteine (Hcy), cysteine (Cys), glutathione (GSH) and cysteinylglycine (CysGly) in the blood serum by means of high performance liquid chromatography (HPLC).
Results. It has been found that in women with surgical menopause, the median value of homocysteine, cysteine, cysteinylglycine is 1.5 times, by 17.0% and 23.2%, respectively, higher than in women with natural menopause and 2.2, 2.0 and 1.8 times, respectively, higher than in the control group patients (p<0.05). The median concentration of glutathione in the blood in patients with surgical menopause was reduced (by 26.7% (p<0.01)), in patients with natural menopause – by 16.2% lower (p<0.05) than in the control group.
The increase in the severity of the climacteric syndrome (CS) according to the Kupperman-Uvarova scale corresponded to an increase in Hcy, Cys, CysGly and a decrease in GSH in the blood serum of the examined women (p<0.01).
Conclusions. The established direct and inverse statistically significant correlations between indicators of the concentration of sulfur-containing amino acids (their derivatives) and gonadotropic, steroid sex hormones and clinical manifestations of climacteric syndrome testify to the participation of the studied indicators in the development of the menopausal period pathology.
Key words: oophorectomy, surgical menopause, natural menopause, climacteric syndrome, hormones, homocysteine (Hcy), cysteine (Cys), cysteinylglycine (CysGly), glutathione (GSH).
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Information about authors:
Kolbasova E.A. – Candidate of Medical Sciences, associate professor of the Chair of Obstetrics and Gynecology, Vitebsk State Order of Peoples’ Friendship Medical University;
Kiseleva N.I. – Doctor of Medical Sciences, professor, head of the Chair of Obstetrics and Gynecology, Vitebsk State Order of Peoples’ Friendship Medical University;
Naumov A.V. – Candidate of Medical Sciences, associate professor of the Chair of Biological Chemistry, Grodno State Medical University.