DOI: https://doi.org/10.22263/2312-4156.2022.3.94
O.V. Mushkina, N.G. Krautsova-Kukhmar, N.S. Gurina, N.V. Shakavets, T.V. Kidyasova
The use of phytogel with tincture of black alder leaves in experimental gingivitis
Belarusian State Medical University, Minsk, Republic of Belarus
Vestnik VGMU. 2022;21(3):94-101.
Abstract.
Objectives. To determine the dynamics of clinical and cytological parameters of the gingival mucosa in the treatment of experimental gingivitis with a phytopreparation based on black alder leaves tincture.
Material and methods. The effectiveness of phytogel containing black alder leaves tincture was evaluated on the model of experimental gingivitis caused in Wistar rats by injecting 0.2 ml of Vipraksin (an aqueous solution of the viper’s venom) into the submucosal layer of the gum. Phytogel and the comparison drug Metrogil Denta were applied 1 or 2 times a day with an interval of 8 hours during 2 (4) days in the corresponding groups.
Results and conclusion. The effectiveness of phytogel with alcohol extraction from the leaves of black alder in experimental gingivitis has been studied, depending on the frequency of use and duration of treatment.
It has been found out that the double use of phytogel containing black alder leaves tincture during 4 days in experimental gingivitis leads to the disappearance of clinical symptoms and complete restoration of the gum structure. With a similar scheme of using Metrogil Denta gel, clinical symptoms disappear, the basal layer of the gingival mucosa is restored, but the histological sign of an inflammation – intracellular edema of the epithelium of the spinous layer remains, which indicates the high effectiveness of the developed herbal preparation in experimental gingivitis.
Keywords: gingivitis, phytogel, black alder, inflammation, histological examination.
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Information about authors:
O.V. Mushkina – Candidate of Pharmaceutical Sciences, associate professor, head of the Chair of Organization of Pharmacy, Belarusian State Medical University, https://orcid.org/0000-0002-3397-1220
E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Olga V. Mushkina;
N.G. Krautsova-Kukhmar – lecturer of the Chair of Pediatric Dentistry, Belarusian State Medical University;
N.S. Gurina – Doctor of Biological Sciences, professor, dean of the pharmaceutical faculty, Belarusian State Medical University;
N.V. Shakavets – Doctor of Medical Sciences, professor, head of the Chair of Pediatric Dentistry, Belarusian State Medical University, https://orcid.org/0000-0002-8811-9545
T.V. Kidyasova – lecturer of the Chair of Operative Surgery and Topographic Anatomy, Belarusian State Medical University.
