DOI: https://doi.org/10.22263/2312-4156.2022.4.9
M.A. Miadzelets, V.A. Miadzelets, A.D. Miadzelets
Morphoneuroimmunoendocrine relationships in local (tissue) homeostasis of the skin epidermis and its barrier-protective functions. Part 1
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2022;21(4):9-19.
Abstract.
The review opens a series of planned articles on the morphoneuroimmunoendocrine system of the skin (MNIESS). In the series it is planned to consider in detail morphology, local nervous, immune and endocrine systems of the skin as a general covering of the body, involved in ensuring its structural homeostasis. In the present article these issues are touched upon in relation to the epidermis as the outermost tissue of the skin. These issues are also raised in terms of neuroimmunoendocrinology of the skin – a branch of dermatology that has been intensively developing in recent years. At the same time, there is no indication in the title of this section that the central link in the ideas about the neuroimmunoendocrine system of the skin should be morphology, i.e., a structure that determines the most primary and most important function of the skin – barrier-protective, because other numerous functions of this organ rely on it. In order to fill this gap, the authors propose to include as an important component main cells of the epidermis – keratinocytes in the complex of local factors ensuring tissue homeostasis of the skin. These cells are considered in this review not only from the standpoint of their ability to turn into a powerful barrier to harmful environmental factors – keratin, but also as cells involved in the nervous, immune and endocrine components of local tissue homeostasis. The structure of the epidermis as a stratified squamous keratinizing epithelium, which is part of two main types of cells: keratinocytes and melanocytes, is also considered in detail. The issues of the unity of structural, nervous, immune and endocrine mechanisms of tissue homeostasis regulation of the epidermis, the participation of keratinocytes in neuro-, immune- and endocrine processes to ensure the barrier-protective function of the skin are raised.
Keywords: skin, local skin homeostasis, neuroimmunoendocrine relationships in the local homeostasis of the epidermis.
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Information about authors:
M.A. Miadzelets – Candidate of Medical Sciences, associate professor of the Chair of Dermatovenerology & Cosmetology, Vitebsk State Order of Peoples’ Friendship Medical University,
E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Maryiana A. Miadzelets;
V.A. Miadzelets – Candidate of Medical Sciences, associate professor of the Chair of Dermatovenerology & Cosmetology, Vitebsk State Order of Peoples’ Friendship Medical University;
A.D. Miadzelets – Doctor of Medical Sciences, professor, head of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University.
