Menu

A+ A A-

Download article

DOI: https://doi.org/10.22263/2312-4156.2022.5.22

A.M. Sharapkova, O.S. Zykova
Cheilitis: general issues of diagnosing
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2022;21(5):22-32.

Abstract.
In modern scientific research, the problem of diagnosing and treatment of inflammatory diseases of the oral mucosa (OM) and the red border of the lips (RBL) remains relevant. Over the last three decades, significant progress has been made in understanding the pathogenesis of these diseases. The results of the study of significant triggers of cheilitis associated with genetic, immunological and environmental impacts are the basis for the development of new methods of treatment. The present article is a review of scientific studies and literature sources on the causes of primary inflammatory diseases of the lips and their early diagnosis. The article presents descriptions of clinical cases of primary cheilitis with the illustrative materials from the authors’ practice. Also, special attention is paid to the principles of diagnosing cheilitis as a symptom complex and as an independent disease, which is of high medical significance for further successful treatment.
Keywords: cheilitis, diseases of the red border of the lips, oral mucosa, diagnosing.

References

1. Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T. Differential Diagnosis of Cheilitis - How to Classify Cheilitis? Acta Clin Croat. 2018 Jun;57(2):342-351. doi: http://dx.doi.org/10.20471/acc.2018.57.02.16
2. Anisimova IV, Nedoseko VB, Lomiashvili LM. Diseases of the mucous membrane of the mouth and lips. Moscow, RF: MEDI; 2005. 92 р. (In Russ.)
3. Cheng AG, DeDent AC, Schneewind O, Missiakas D. A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol. 2011 May;19(5):225-32. doi: http://dx.doi.org/10.1016/j.tim.2011.01.007
4. Боровский ЕВ, Машкилейсон АЛ, ред. Заболевания слизистой оболочки полости рта и губ. Москва, РФ: МЕДпресс Borovskiy EV, Mashkileĭson AL, red. Diseases of the mucous membrane of the mouth and lips. Moscow, RF: MEDpress; 2001. 162 р.
5. Litaiem N, Slimane MB, Bacha T, Rammeh S, Zeglaoui F. Cheilitis with hemorrhagic crusts of the vermilion lips. Int J Dermatol. 2020 Jul;59(7):e234-e236. doi: http://dx.doi.org/10.1111/ijd.14814
6. Ohta K, Yoshimura H. Candida-Associated Cheilitis. Am J Med Sci. 2020 Dec;360(6):e17-e18. doi: http://dx.doi.org/10.1016/j.amjms.2020.05.046
7. Oza N, Doshi JJ. Angular cheilitis: A clinical and microbial study. Indian J Dent Res. 2017 Nov-Dec;28(6):661-665. doi: http://dx.doi.org/10.4103/ijdr.IJDR_668_16
8. Schwarz I, Bokanovic D, Aberer W. Mucosal diseases from an allergological perspective. Hautarzt. 2016 Aug;67(10):780-5. doi: http://dx.doi.org/10.1007/S00105-016-3866-3
9. Lutskaya IK. Clinical manifestations of independent lip diseases. Med Novosti. 2011;(11):4-8. (In Russ.)
10. Oza N, Doshi JJ. Angular cheilitis: A clinical and microbial study. Indian J Dent Res. 2017 Nov-Dec;28(6):661-665. doi: http://dx.doi.org/10.4103/ijdr.IJDR_668_16
11. Gonzaga AKG, Mafra RP, da Silva LP, de Almeida FR, de Souza LB, Pinto LP. Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. Acta Histochemica. 2020 Jan;122(1):151452. doi: http://dx.doi.org/10.1016/j.acthis.2019.151452
12. de Carvalho LFCES, Pereira TM, Magrini TD, Cavalcante ASR, da Silva Martinho H, Almeida JD. Optical diagnosis of actinic cheilitis by infrared spectroscopy. Photodiagnosis Photodyn Ther. 2016 Dec;16:27-34. doi: http://dx.doi.org/10.1016/j.pdpdt.2016.07.013
13. Zaykov SV. Diagnosis and treatment of allergic diseases of the lips. Novosti Meditsiny Farmatsii. 2014;(1-2):14-16. (In Russ.)
14. Duvancić T, Lugović-Mihić L, Brekalo A, Situm M, Sinković A. Prominent features of allergic angioedema on oral mucosa. Acta Clin Croat. 2011 Dec;50(4):531-8.
15. Salgueiro AP, de Jesus LH, de Souza IF, Rados PV, Visioli F. Treatment of actinic cheilitis: a systematic review. Clin Oral Investig. 2019 May;23(5):2041-2053. doi: http://dx.doi.org/10.1007/s00784-019-02895-z
16. Sarkar S, Ghosh S, Sengupta D. Clinically granulomatous cheilitis with plasma cells. Indian Dermatol Online J. 2016 Mar-Apr;7(2):96-8. doi: http://dx.doi.org/10.4103/2229-5178.178094
17. Jin J. Actinic cheilitis or discoid lupus erythematosus? Arch Dermatol Res. 2021 Dec;313(10):889-890. doi: http://dx.doi.org/10.1007/s00403-021-02192-4
18. Lai M, Pampena R, Cornacchia L, Pellacani G, Peris K, Longo C. Treatments of actinic cheilitis: A systematic review of the literature. J Am Acad Dermatol. 2020 Sep;83(3):876-887. doi: http://dx.doi.org/10.1016/j.jaad.2019.07.106
19. Trager MH, Farmer K, Ulrich C, Basset-Seguin N, Herms F, Geskin LJ, et al. Actinic cheilitis: a systematic review of treatment options. J Eur Acad Dermatol Venereol. 2021 Apr;35(4):815-823. doi: http://dx.doi.org/10.1111/jdv.16995
20. O’Gorman SM, Torgerson RR. Contact allergy in cheilitis. Int J Dermatol. 2016 Jul;55(7):e386-91. doi: http://dx.doi.org/10.1111/ijd.13044
21. Pilati S, Bianco BC, Vieira D, F Modolo. Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. Oral Dis. 2017 Mar;23(2):219-224. doi: http://dx.doi.org/10.1111/odi.12597
22. Samimi M. Chéilites: orientation diagnostique et traitement. Presse Med. 2016 Fev;45(2):240-50. doi: http://dx.doi.org/10.1016/j.lpm.2015.09.024
23. Salgueiro AP, de Jesus LH, de Souza IF, Rados PV, Visioli F. Treatment of actinic cheilitis: a systematic review. Clin Oral Investig. 2019 May;23(5):2041-2053. doi: http://dx.doi.org/10.1007/s00784-019-02895-z
24. Friedrich RE, Löning T. Cheilitis glandularis: case report with respect to immunohistochemical findings. GMS Interdiscip Plast Reconstr Surg DGPW. 2016 Jan;5:Doc04. doi: http://dx.doi.org/10.3205/iprs00008
25. Samimi M. Cheilitis: diagnosis and treatment. Presse Med. 2016 Feb;45(2):240-50. doi: http://dx.doi.org/10.1016/j.lpm.2015.09.024
26. Abhishek K, Rashmi J. Plasma Cell Gingivitis Associated with Inflammatory chelitis: a report on a rare case. Ethiop J Health Sci. 2013 Jul;23(2):183-7.
27. Macklis P, Adams K, Kaffenberger J, Kumar P, Krispinsky A, Kaffenberger B. The Association Between Oral Health and Skin Disease. J Clin Aesthet Dermatol. 2020 Jun;13(6):48-53.
28. Hu X, Xing Y, Mu C, Liu Y, Hua H. Association between cheilitis granulomatosa and odontogenic infections: A case-control study. J Dermatol. 2021 Nov;48(11):1731-8. doi: http://dx.doi.org/10.1111/1346-8138.16108
29. Cabras M, Gambino A, Broccoletti R, Lodi G, Arduino PG. Treatment of angular cheilitis: A narrative review and authors’ clinical experience. Oral Dis. 2019 Aug. doi: http://dx.doi.org/10.1111/odi.13183
30. Sil A, Priyam P. Lip Smacker’s Cheilitis Indian Pediatr. Indian Pediatr. 2019 Dec;56(12):1083.
31. Ständer S. Atopic dermatitis / S. Ständer. N Engl J Med. 2021 Mar 25;384(12):1136-1143. doi: http://dx.doi.org/10.1056/NEJMra2023911
32. Cabanillas B, Brehler A-C, Novak N. Atopic dermatitis phenotypes and the need for personalized medicine. Curr Opin Allergy Clin Immunol. 2017 Aug;17(4):309-315. doi: http://dx.doi.org/10.1097/ACI.0000000000000376
33. Oliveira ADT, Sodré CS, de Carvalho Ferreira D, de Dios Abad E, Saintive S, Ribeiro M, et al. Oral Aspects Identified in Atopic Dermatitis Patients: A Literature Review. Open Dent J. 2018 May;12:424-434. doi: http://dx.doi.org/10.2174/1874210601812010424
34. Suárez-Fariñas M, Dhingra N, Gittler J, Shemer A, Cardinale I, de Guzman Strong C, et al. Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune activation compared to extrinsic AD. J Allergy Clin Immunol. 2013 Aug;132(2):361-70. doi: http://dx.doi.org/10.1016/j.jaci.2013.04.046
35. Tollefson MM, Bruckner AL. Atopic dermatitis: skin-directed management. Pediatrics. 2014 Dec;134(6):e1735-44. doi: http://dx.doi.org/10.1542/peds.2014-2812
36. Danilevskiy NF, Leontyev VK, Nesin AF, Rakhniy ZhI. Diseases of the oral mucosa. Moscow, RF: Stomatologiya; 2001. 271 р.
37. Bhutta BS, Hafsi W. Cheilitis. In: Aba B, Abu-Ghosh A, Acharya AB, Adhia SG, Sedeh PA, Aeby TC, et al, ed board. StatPearls Publishing LLC; 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553074/. [Accessed 29th September 2022].
38. Wehl G, Rauchenzauner M. A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome. Curr Pediatr Rev. 2018;14(3):196-203. doi: http://dx.doi.org/10.2174/1573396314666180515113941
39. Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, et al. Expression profiles and modulation by triggering factors. J Invest Dermatol. 2012 May;132(5):1392-400. doi: http://dx.doi.org/10.1038/jid.2011.446
40. Lee HJ, Lee SH. Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis. Allergy Asthma Immunol Res. 2014 Jul;6(4):276-87. doi: http://dx.doi.org/10.4168/aair.2014.6.4.276
41. Lebwohl MG, Del Rosso JQ, Abramovits W, Berman B, Cohen DE, Guttman E, et al. Pathway to managing atopic dermatitis: consensus from the experts. J Clin Aesthet Dermatol. 2013 Jul;6(7 Suppl):S2-S18.
42. Pastuszka M, Matych M, Kaszuba A, Poznańska-Kurowska K. Microorganisms n the etiopathogenesis of atopic dermatitis. Postep Derm Alergol. 2012;29(3):215-21.
43. Frazier W, Bhardwaj N. Atopic Dermatitis: Diagnosis and Treatment. Am Fam Physician. 2020 May;101(10):590-598.
44. Cheng AG, DeDent AC, Schneewind O, Missiakas D. A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol. 2011 May;19(5):225-32. doi: http://dx.doi.org/10.1016/j.tim.2011.01.007
45. Puar N, Chovatiya R, Paller AS. New treatments in atopic dermatitis. Ann Allergy Asthma Immunol. 2021 Jan;126(1):21-31. doi: http://dx.doi.org/10.1016/j.anai.2020.08.016

Information about authors:
A.M. Sharapkova – senior teacher of the Chair of General & Prosthetic Dentistry with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Alina M. Sharapkova;
O.S. Zykova – Candidate of Medical Sciences, associate professor of the Chair of Dermatovenerology & Cosmetology, Vitebsk State Order of Peoples’ Friendship Medical University.

Поиск по сайту