DOI: https://doi.org/10.22263/2312-4156.2022.6.64
E.L. Stavchikov, I.V. Zinovkin, A.V. Marochkov
The evaluation of clinical efficacy of bioplastic Collost material in the treatment of chronic wounds in patients with diabetic foot syndrome
Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus
Vestnik VGMU. 2022;21(6):64-70.
Abstract.
Objectives. To evaluate the clinical effectiveness of the use of bioplastic collagenous material Collost in the treatment of chronic wounds in patients with diabetic foot syndrome (DFS).
Material and methods. The study involved 35 patients with DFS having chronic wounds on the lower extremities accompanied by type 2 diabetes mellitus. Patients with DFS in the comparison group received standard treatment. In the main group, standard treatment was supplemented with local application of Collost collagen biomaterial in the form of a membrane of different size depending on the area of the wound surface. The mobile Wound Analysis application (USA) evaluated the quantitative characteristics of the wound surface.
Results. On the 28th day of treatment, a significant difference between the groups (p<0.05) was established with regard to the reduction of the total area of the wound from 3.32 cm2 to 1.45 cm2 (2.29 times) in the main group and in the comparison group from 3.87 cm2 to 2.89 cm2 (1.34 times). Complete epithelialization of the wound was observed by the 28th day in 8 cases (22.8%), including 6 cases in the main group (35.3%) and 2 patients from the comparison group (11.1%). The area of the wound with purulent fibrin plaque after administered treatment in the main group decreased (p<0.05) from 1.73 cm2 to 0.42 cm2 (4.12 times), in the comparison group – from 2.02 cm2 to 0.64 cm2 (3.15 times). The area of granulation tissue in the main group decreased (p>0.05) from 1.59 cm2 to 1.03 cm2 (1.54 times) due to the cases of complete epithelization of wound surfaces, in the comparison group it increased (p>0.05) from 1.85 cm2 to 2.25 cm2 (1.21 times).
Conclusions. The use of Collost collagen biomaterial in patients with DFS after 28 days of treatment leads to a more significant reduction 2.29 times in the total area of the wound surface of chronic wounds, 4.12 times decrease in the area of purulent-fibrin plaque, a three-fold increase in the frequency of cases of complete epithelialization of the wound. The use of collagen containing biomaterials in the complex treatment of patients with DFS exerts a positive effect on the dynamics of the wound process in chronic wounds.
Keywords: diabetic foot syndrome, chronic wound, Collost.
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Information about authors:
E.L. Stavchikov – surgeon of the department of purulent surgery, Mogilev Regional Clinical Hospital, https://orcid.org/0000-0001-5147-5274
E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Evgeny L. Stavchikov;
I.V. Zinovkin – head of the department of purulent surgery, Mogilev Regional Clinical Hospital;
A.V. Marochkov – Doctor of Medical Sciences, professor, anesthesiologist-resuscitator, head of the Practical-Scientific Division, Mogilev Regional Clinical Hospital, https://orcid.org/0000-0001-5092-8315
