DOI: https://doi.org/10.22263/2312-4156.2023.4.105
I.L. Kurs
Analysis of the range of herbal medicines registered in the Republic of Belarus
Belarusian State Medical University, Minsk, Republic of Belarus
Vestnik VGMU. 2023;22(4):105-121.
Abstract.
Objectives. To investigate the range of herbal medicines (HM) registered in the Republic of Belarus.
Material and methods. The data of the Register of Medicines of the Republic of Belarus of the Republican Unitary Enterprise «Center for Expertise and Testing in HealthCare» (State register of medicines) were analyzed. The analysis of the range of HM registered in the Republic of Belarus was carried out according to the following criteria: «country of production», «manufacturer», «composition», «originality», «dosage form (DF)», «group according to anatomical-therapeutic-chemical (ATC) classification».
Results. The share of HM in the period from 01.01.2017 to 01.01.2021 varied from 11.6 to 13.5% of all medicines registered in the Republic of Belarus and as of 01.01.2021 amounted to 12.1%. According to the criterion «composition» monocomponent drugs prevailed among HM in the period 2017-2021, according to the criterion «originality» – generic ones. In the study period, the nomenclature of countries whose HM were registered in the Republic of Belarus decreased from 25 to 23, the nomenclature of manufacturing plants decreased from 114 to 95. The nomenclature of DF of HM in the study period varied from 36 to 43, as of 01.01.2021 made up 39 DF. In the study period most of the HM were presented in the form of packaged raw materials and in bulk. According to the criterion «group according to ATC classification» HM used in the treatment of diseases of the digestive tract and metabolic diseases prevailed in the study period.
Conclusions. The identified trends in the registration of HM determine the relevance and prospects for the development and production of combined HM of domestic production, the expansion of the range of HM DF in the domestic segment, as well as the increase in the range of HM from the ATC classification groups: anti-infective agents for systemic use (including antiviral), antiparasitic drugs, drugs for the treatment of eye diseases.
Keywords: herbal medicines, State Register of Medicines of the Republic of Belarus, marketing research, assortment, pharmaceutical market, macrocontour.
References
1. Selimzyanova LR, Vishneva EA, Fedoseenko MV, Promyslova EA. Phytotherapy: current status of the issue. Pediatr Farmakologiya. 2016;13(5):488-93. doi: http://dx.doi.org/10.15690/pf.v13i5.1645 (In Russ.)
2. Fayzullina RA, Samorodnova EA, Shoshina NK. Opportunities of phytotherapy in pediatric practice. Prakt Meditsina. 2009;(7):84-8. (In Russ.)
3. Т Toktonaliev IU. Place and role of phytopreparations in modern medical practice science. Nauka Novye Tekhnologii Innovatsii Kyrgyzstana. 2017;(7):108-11. (In Russ.)
4. Kurs IL, Gurina NS. Analysis of the nomenclature of herbal medicines registered in the Republic of Belarus. V: M-vo zdravookhraneniya Respubliki Belarus', Bel gos med un-t; Sikorskii AV, Khryshchanovich VYa, redkol. BGMU v avangarde meditsinskoi nauki i praktiki: retsenzir sb nauch tr. Minsk, RB: BGMU; 2019. Vyp 9. Р. 347-53. (In Russ.)
5. Ershova IB, Osipova TF. General requirements for the preparation of tinctures, decoctions. Dosing of phytopreparations. Aktual Infektologiya. 2016;(3):123-7. doi: http://dx.doi.org/10.22141/2312-413x.3.12.2016.81727 (In Russ.)
6. World Health Organization. WHO traditional medicine strategy: 2014-2023. Avaiable from: https://www.who.int/publications/i/item/9789241506096 [Accessed 22th September 2022].
7. Danilyuk OA. Phytotherapy of cough in children. Vopr Sovrem Pediatrii. 2008;7(4):120-5. (In Russ.)
8. Reshetnikov VN, Gapanovich VN, Volodko IK. State national economic program of development of raw material base and processing of medicinal and spicy aromatic plants for 2005-2010 "Phytopreparations" - innovations in action. Tr Belorus Gos Un-ta. 2010;5(ch 2):10-5. (In Russ.)
9. Kholodova IN. Modern phytotherapy: possibilities and prospects of its use in treatment programs in children. Med Sovet. 2017;(1):122-7. (In Russ.)
10. Sambukova TV, Ovchinnikov BV, Ganapolskiy VP. Prospects for the use of phytopreparations in modern pharmacology. Obzory Klin Farmakologii Lekarstv Terapii. 2017;15(2):56-63. doi: http://dx.doi.org/10.17816/RCF15256-63 (In Russ.)
11. Shirokova I. Phytopreparations market - trends, challenges, forecasts. Remedium. 2013;(4):26-32. (In Russ.)
12. RUP Tsentr ekspertiz i ispytanii v zdravookhranenii. State Register of Medicines of the Republic of Belarus. Avaiable from: https://rceth.by/Refbank/ [Accessed 22th September 2022]. (In Russ.)
13. Dobrynina NF. Statistical methods for predicting the quality of mathematics education. Fundam Issled. 2009;(1):13-5. (In Russ.)
14. Akamova AV, Nemyatykh OD, Narkevich IA. Multidirectional marketing analysis of the Russian phytopreparations market. Razrabotka Registratsiya Lekarstv Sredstv. 2017;(4):276-80. (In Russ.)
15. Qu L, Li X, Xiong Y, Wang Z, Zhou Y, Zou W, et al. Opportunities and hurdles to European market access for multi-herbal traditional Chinese medicine products: An analysis of EU regulations for combination herbal medicinal products. Pharmacol Res. 2022 Dec;186:106528. doi: http://dx.doi.org/10.1016/j.phrs.2022.106528
16. Poudel A, Alam K, Palaian S, Mohamed Izham Mohamed Ibrahim. Herbal Fixed Dose Combinations in Nepal: Growing Concerns in a Developing Country. J Clin Diagn Res. 2016 Oct;10(10):FM01-FM03. doi: http://dx.doi.org/10.7860/JCDR/2016/20519.8686
17. Dobrovolskiy AV. Approaches to clinical development of combination medicines in the Russian Federation and the Eurasian Economic Union, taking into account the requirements of current legislation. Ved Nauch Tsentra Ekspertizy Sredstv Med Primeneniya. 2019;9(1):14-27. (In Russ.)
18. Sampiev AM, Nikiforova EB, Gamagina MV. Relevance of research on the development of drugs with polyfunctional action, combining pharmaceutical substances of natural and synthetic origin. Pul's. 2020;22(1):80-5. doi: http://dx.doi.org/10.26787/nydha-2686-6838-2020-22-l-80-85 (In Russ.)
19. Tegtmeier M, Knierim L, Schmidt A, Strube J. Green Manufacturingfor Herbal Remedieswith Advanced Pharmaceutical Technology. Pharmaceutics. 2023 Jan;15(1):188. doi: http://dx.doi.org/10.3390/pharmaceutics15010188
20. Sakaeva IV, Bunyatyan ND, Sakanyan EI, Shishova LI, Korsun LV, Mochikina OA, i dr. Medicines of plant origin in modern dosage forms: characterization and classification. Ved Nauch Tsentra Ekspertizy Sredstv Med Primeneniya. 2013;(4):51-8. (In Russ.)
21. Bueva VV, Blynskaya EV, Alekseev KV, Tishkov SV, Alekseev VK, Ivanov AA. Analysis of the current status of pharmaceuticals in the dosage form of chewable tablets. Vestn Novykh Med Tekhnologii. 2020;14(6):115-9. doi: http://dx.doi.org/10.24411/2075-4094-2020-16736 (In Russ.)
22. Gammel IV, Gorbunova SA. Study of the assortment of medicines in hard gelatin capsules. Med Al'm. 2018;(1):121-5. (In Russ.)
23. Golovkin DN, Sharova OV, Kurkina AV. Concepts of phytotherapy in the practice of a pediatrician. Sovrem Problemy Nauki Obrazovaniya. 2017;(5). Avaiable from: https://science-education.ru/ru/article/view?id=27083. [Accessed 22th September 2022]. (In Russ.)
24. Egorova SN, Kondakov SE, Gordeev VV, Beletskiy SO, Khayatov AR, Ikhalaynen ES. Current problems of dosing medicines for children in the Russian Federation. Vestn Smolenskoi Gos Med Akad. 2019;18(4):220-8. (In Russ.)
25. Gontarev SN, Gontareva IS, Nikishaeva AV. Use of phytopreparations in pediatric dentistry. Nauch Rezul'taty Biomed Issled. 2016;2(2):17-21. doi: http://dx.doi.org/10.18413/2313-8955-2016-2-2-17-21 (In Russ.)
26. Goncharova EI. Preparations of medicinal plants in the treatment of diseases of the oral mucosa. Ros Stomatol Zhurn. 2015;19(4):55-7. (In Russ.)
27. M-vo zdravookhraneniya Resp Belarus', GU Resp nauch-prakt tsentr med tekhnologii, informatizatsii, upravleniya i ekonomiki zdravookhraneniya. Health care in the Republic of Belarus: ofits stat sb za 2019 g. Minsk, RB: GU RNPTs MT; 2019. 257 р. (In Russ.)
28. Chistyakova ES, Zorina IG, Artemyev KA. Comparative analysis of the epidemiological situation of infectious diseases in the Russian Federation and the Republic of Belarus. COGNITIO RERUM. 2021;(7):65-9. (In Russ.)
29. Butko DYu, Barantsevich ER, Voznyuk IA, Danilenko LA, Starikov SM. Possibilities of using herbal combination medicines in the treatment and rehabilitation of patients with acute respiratory viral infections in COVID-19 pandemic conditions. Akad Meditsiny Sporta. 2020;1(2):23-7. doi: http://dx.doi.org/10.15829/2712-7567-2020-2-11 (In Russ.)
30. Romanenko IA. Efficacy of bilberry preparations in ophthalmology: clinical observations. Klin Oftal'mologiya. 2011;12(1):32-4. (In Russ.)
31. Pleskanovskaya SA, Annanepesov AK, Karanov KS. Immunologic approach to the choice of phytotherapy for open-angle glaucoma. Vostoch-Evrop Nauch Zhurn. 2023;(3, ch 2):44-7. (In Russ.)
32. Nasakaeva GE. Clinic, diagnosis, treatment of giardiasis at the present stage. Meditsina Ekologiya. 2010;(4):213-6. (In Russ.)
33. Akhmetova SB, Timchenko NA, Loseva IV, Dedova OYu, Almagambetov KKh. Effectiveness of phytopreparations in the treatment of various parasitic infestations. Meditsina Ekologiya. 2009;(4):9-16. (In Russ.)
Information about authors:
I.L. Kurs – Master of Pharmaceutical Sciences, postgraduate of the Chair of Pharmacy Organization, Belarusian State Medical University, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Inga L. Kurs.
