DOI: https://doi.org/10.22263/2312-4156.2023.4.9
A.V. Bialiauski, Е.S. Pashinskaya, V.V. Pabiarzhyn
Synaptic plasticity of the mammalian circadian system and expression of synaptic genes
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2023;22(4):9-20.
Abstract.
The vital activity of humans and other animals involves constant structural changes in the CNS. During learning, memorizing information and behavior, rearrangements in the bodies of neurons, nerve endings and synaptic connections take place in the nervous centers. Neurons, glial cells and synapses in the brain of both invertebrates and vertebrates possess plasticity, in other words their structure and physiology change in response to internal and external stimuli. As a result, the morphology of neurons and neuronal networks are constantly modified in response to various irritants. In mammals, it has been found that the number of synapses, the size and shape of neurons change rhythmically throughout the day, that is these changes are circadian. They are generated by endogenous circadian clocks, but some rhythmic changes in the morphology of neurons, the number and structure of synapses are directly controlled by the environmental signals or both by external signals and circadian clocks. Neurons forming central clocks not only regulate the circadian plasticity of the brain, but also undergo circadian changes in their own processes. Accordingly, various factors of the external and internal environment affecting the synaptic plasticity of the circadian system components may be the cause of various pathological processes in the mammalian body. The effect of parasitic diseases on the functions of the circadian system is of particular interest, but there are few researches of this kind.
Keywords: synaptic plasticity, circadian system, synaptic genes, receptors.
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Information about authors:
A.V. Bialiauski – postgraduate of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
e mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Aleg V. Bialiauski;
Е.S. Pashinskaya – Candidate of Biological Sciences, associate professor, head of the Scientific and Educational Center “Center for Molecular Genetic and Biotechnological Research”, Vitebsk State Order of Peoples’ Friendship Medical University;
V.V. Pabiarzhyn – Candidate of Biological Sciences, associate professor of the Chair of Biology & Pharmaceutical Botany, Vitebsk State Order of Peoples’ Friendship Medical University.
